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Systems Biology and Bioimaging

Systems Biology as a Driver for Industrial Biotechnology

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In an EC funded coordination and support action FCC collaborates closely with the Systems Biology lab at Chalmers, who coordinates this 21 partner project. A joint PhD project forms the basis of a work package lead by FCC on dynamic models for design of metabolic engineering strategies.

The overall goal of SYSINBIO is to coordinate research activities in the field of model driven metabolic engineering in Europe and coordinate how systems biology can be used to improve the performance of metabolic models and further how mathematical models can be used for improved design of cell factories used in industrial biotechnology. In this project FCC manage a workpackage with the objective to coordinate the development of dynamic models for design of metabolic engineering strategies. Here we will exchange and develop concepts and methods for setting up dynamic models. Furthermore, we will develop and exchange existing efficient workflows for setting up and analyzing dynamic models of metabolic reaction networks including parameter estimation, model validation and discrimination, and simulation. The project is coordinated by Professor Jens Nielsen at Chalmers and includes 21 partners from both industry and academia.

 

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About us

Systems Biology and BioiMAGING

We provide an integrated approach to the study of biochemical and physiological processes, from the characterization of single parts to the analysis of dynamic phenomena on a systems level. The work at the department includes both biological and biomedical modeling applications as well as development of computational tools and algorithms. Our focus areas are:

We receive substantial funding from the Swedish Foundation for Strategic Research (SSF). We have close collaborations with local partners and initiatives such as the Systems Biology group at the Department of Chemical and Biological Engineering, the Gothenburg Mathematical Modelling Center (GMMC),  Chalmers Biocenter, the Bionanophotonics Division of the Department of Applied Physics at Chalmers, and the Department of Cell- and Molecular Biology (CMB) at Gothenburg University. On the international level we are part of the BIOSIM network of excellence, the Yeast Systems Biology Network (YSBN), and the UNICELLSYS, CANCERSYS and SYSINBIO projects.