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Mathematics as a Technology

Our vision reflects the fact that mathematics has become a key technology for industrial innovation, lying behind all work in the virtual world - simulation for prediction, control, optimization, quality assurance, and risk assessment.

Systems and Data Analysis

Kinetic models in industrial biotechnology – Improving cell factory performance

Timescales

J. Almquist, M. Cvijovic, V. Hatzimanikatis, J. Nielsen, and M. Jirstrand. Metabolic Engineering 24 (2014) 38-60.

Systems and Data Analysis

Bridging the gaps in systems biology

FutureSysBio

M. Cvijovic, J. Almquist, J. Hagmar, S. Hohmann, H.-M. Kaltenbach, E. Klipp, M. Krantz, P. Mendes, S. Nelander, J. Nielsen, A. Pagnani, N. Przulj, A. Raue, J. Stelling, S. Stoma, F. Tobin, J.A.H. Wodke, R. Zecchina, M. Jirstrand. Molecular Genetics and Genomics, April 2014, [Epub ahead of print].

Systems and Data Analysis

Yeast AMP-Activated Protein Kinase Monitors Glucose Concentration Changes as well as Absolute Glucose Levels

Figure 1

L. Bendrioua, M. Smedh, J. Almquist, M. Cvijovic, M. Jirstrand, M. Goksör, C. Adiels, and S. Hohmann. The Journal of Biological Chemistry, May 2, 2014, 289, 12863-12875.

Systems and Data Analysis

Stochastic differential equations as a tool to regularize the parameter estimation problem for continuous time dynamical systems given discrete time measurements

Contour plot of loglikelihood

J. Leander, T. Lundh, and M. Jirstrand. Mathematical Biosciences, Volume 251, May 2014, Pages 54–62.

Systems and Data Analysis

20 million SEK Synergy Grant in Applied Mathematics

SSF

The Swedish Foundation for Strategic Research, SSF, funds a five year project entitled Hierarchical Mixed Effects Modeling of Dynamical Systems with 20 million SEK.

Systems and Data Analysis

Maxsim2—Real-time interactive simulations for computer-assisted teaching of pharmacokinetics and pharmacodynamics

Physiologically Based Pharmacokinetic Models

J. Gabrielsson, K. Andersson, G. Tobin, C. Ingvast-Larsson, and M. Jirstrand. Computer Methods and Programs in Biomedicine 2014, 113(3):815-829.