Evaluation and Optimization of Model-based Translations in Oncology – From Xenografts to RECIST

M. Baaz, T. Cardilin, F, Lignet, M. Jirstrand. Drug/Disease Modelling - Oncology, PAGE 29 (2021) Abstr 9754, 2-7 September 2021.

Abstract


Objectives:

  1. Evaluate currently used translational methods in oncology using preclinical (xenograft data) and clinical data (response rate based on RECIST v1.1) for several drug combinations.

  2. Use mathematical optimization to investigate alternative ways of scaling PD parameters from mouse to human.




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