NLMEModeling is a Mathematica application for parameter estimation of nonlinear mixed-effects models of dynamical systems given time-series data from a set of subjects.

Models are specified in terms of parametrized systems of ordinary or stochastic differential equations together with a set of observation expressions. The application provides functions for parameter estimation, model validation, visualization of population data and model predictions, and simulation for synthetic data generation.

The application and the methods used are described in the publications

The application package can be obtained by sending a request to

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