An updated phylogeny of the metallo-β-lactamases

F. Berglund, A. Johnning, D. G-J. Larsson, E. Kristiansson. Journal of Antimicrobial Chemotherapy, dkaa392, 2 October 2020


Metallo-β-lactamases (MBLs) are enzymes that use zinc-dependent hydrolysis to confer resistance to almost all available β-lactam antibiotics. They are hypothesized to originate from commensal and environmental bacteria, from where some have mobilized and transferred horizontally to pathogens. The current phylogeny of MBLs, however, is biased as it is founded largely on genes encountered in pathogenic bacteria. This incompleteness is emphasized by recent findings of environmental MBLs with new forms of zinc binding sites and atypical functional profiles.

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