Abstract
Essentials
- MEDI2452 is a specific antidote of the platelet P2Y12 receptor antagonist ticagrelor.
- Hemostatic effects of MEDI2452 were evaluated in pigs treated with ticagrelor and aspirin.
- MEDI2452 eliminated free ticagrelor within 5 min and gradually normalized platelet aggregation.
- Improvements in blood pressure (significant) and in blood-loss and survival (non-significant) were observed.