Investigation of sparse clinical sampling in light of baseline oscillations and between-individual variability using pharmacokinetic/pharmacodynamic modelling

F. Held, C. Ekstrand, J. Gabrielsson, M. Jirstrand. 14th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT), Wroclaw, Poland, 24-27 June 2018.

Abstract

Cortisol exhibits a circadian rhythm in horses. It is a well-known biomarker that is suppressed by dexamethasone. A sampling protocol of cortisol with one pre- and one post drug administration sample is used in dexamethasone suppression tests. However, diurnal fluctuation and inter-individual variation may hamper the utility of test results. The aim of this study was to quantify the determinants of baseline fluctuation and between-individual and between-occasion variability for guidance of an improved test protocol.

Authors and Affiliations

  • Felix Held, Fraunhofer-Chalmers Centre, Gothenburg, Sweden, and Mathematical Sciences, Chalmers and Gothenburg University, Gothenburg, Sweden
  • Carl Ekstrand, Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Division of Pharmacology and Toxicology, Uppsala, Sweden
  • Johan Gabrielsson, Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Division of Pharmacology and Toxicology, Uppsala, Sweden
  • Mats Jirstrand, Fraunhofer-Chalmers Centre, Gothenburg, Sweden

To read more, please click here.




Photo credits: Nic McPhee