Latent antibiotic resistance genes are abundant, diverse, and mobile in human, animal, and environmental microbiomes

J. S. Inda-Díaz, D. Lund, M. Parras-Moltó, A. Johnning, J. Bengtsson-Palme, E. Kristiansson. Microbiome, 11(1), 44. 8 March 2023.


Bacterial communities in humans, animals, and the external environment maintain a large collection of antibiotic resistance genes (ARGs). However, few of these ARGs are well-characterized and thus established in existing resistance gene databases. In contrast, the remaining latent ARGs are typically unknown and overlooked in most sequencing-based studies. Our view of the resistome and its diversity is therefore incomplete, which hampers our ability to assess risk for promotion and spread of yet undiscovered resistance determinants.

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