Model-based estimation of AV-nodal refractory period and conduction delay trends from ECG

M. Karlsson, P. G. Platonov, S. R. Ulimoen, F. Sandberg, M. Wallman. Frontiers in Physiology, Sec. Cardiac Electrophysiology, Vol.14 - 2023. 12 January 2024.


Atrial fibrillation (AF) is the most common arrhythmia, associated with significant burdens to patients and the healthcare system. The atrioventricular (AV) node plays a vital role in regulating heart rate during AF by filtering electrical impulses from the atria. However, it is often insufficient in regards to maintaining a healthy heart rate, thus the AV node properties are modified using rate-control drugs. Moreover, treatment selection during permanent AF is currently done empirically. Quantifying individual differences in diurnal and short-term variability of AV-nodal function could aid in personalized treatment selection.

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